Dihydrocodeine Overdoses in a Neonate and in a 14-year-old Girl Who Were Both Genotyped as Cytochrome P450 2D6*1/*10-*36

Abstract:A high activity of cytochrome P4502D6 ( CYP2D6) reportedly leads to toxicity of dihydrocodeine/ codeineby increasing toxic potential of their metabolite dihydromorphine/morphine, which are further metabolized to highly active dihydromorphine6-O- glucuronideand the less active morphine 3-O-