Renal functional reserve capacity before and after living kidney donation

Compensatory GFR increase after kidney donationresults in a GFR above 50% of the pre- donationvalue. The Renal Functional Reserve assessed by the renal response to dopamine infusion (RFRdopa) is considered to reflect functional reserve capacity and thought to be a tool for living donor screening. However, it is unknown if the RFRdopa predicts long-term kidney function. Between 1984 and 2017, we prospectively measured mGFR (125-I-Iothalamate) and RFR by dopamine infusion in 937 living kidney donors. We performed linear regression analysis of pre- donationRFRdopa and post- donationGFR. In donors with 5-year follow-up after donationwe assessed the association with long-term GFR. Mean donor age was 52±11 years, 52% were female. Mean pre- donationGFR was 114±22 ml/min, GFRdopa was 124±24 ml/min, resulting in a RFR of 9±10 ml/min. Three months post- donation, GFR was 72±15 ml/min and GFRdopa was 75±15 ml/min, indicating that donors still had RFRdopa (3±6 ml/min, P<0.001). Pre- donationRFRdopa was not associate...