Effect of intermittent inhaled tobramycin on sputum cytokine profiles in cystic fibrosis

2005
Objectives: The aim of this study was to evaluate the anti-inflammatory properties of intermittentinhaled tobramycin. Methods: To establish this, we initiated a prospective study to measure the concentration of the three proinflammatorycytokinesIL-8,IL-6andTNF-ainthesputumfrom20cysticfibrosis(CF)patients(15teenagers and 5 young adults) during cycles and off cycles. Results:AsignificantdecreaseinIL-8(P=0.001)andamoremoderatedecreaseinIL-6(P=0.046)andTNF-a (P = 0.052) levels were observed during cycles, even if no significant decrease in the number of leucocytes was observed. Conclusions: These results associated with a decrease in the Pseudomonas aeruginosa population can contribute in part to the beneficial effect of intermittentinhaled tobramycinon pulmonary function.
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