Potential of serum soluble CD93 as a biomarker for asthma in an ovalbumin-induced asthma murine model

AbstractBackground: CD93is a membrane-associated glycoprotein, which can be released in a soluble form (sCD93) into the serum. CD93has received renewed attention as a candidate biomarker of inflammation in various inflammatory and immune-mediated diseases, including asthma.Objective: We aimed to evaluate the effects of airway inflammation on CD93levels in murine models.Methods: We established an ovalbumin(OVA)-induced acute asthma murine model (OVA model) and a lipopolysaccharide (LPS)-induced airway inflammation murine model (LPS model). Dexamethasone was administered by gavage to attenuate the airway inflammation.Results: The OVA model demonstrated typical allergic asthma features with increased airway hyper-responsiveness, inflammatory cell infiltration, increased Th2 cytokine levels, compared to the control group. CD93levels were decreased in lung homogenates and, respiratory epithelial cells, whereas serum sCD93 levels were increased in the OVA model, as compared to the control group. Dexamethas...