Plasma and Cerebrospinal Fluid Indinavir Population Pharmacokinetics in

Plasma and cerebrospinal fluid (CSF) indinavir concentrations were measured by high-performance liquidchromatography. The median concentration in plasma exceeded that in CSF 10-fold. The modeled CSF curvewas flat at 155 nM, and the estimated ratio of the areas under the CSF and plasma concentration-time curveswas 6%. We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical95% inhibitory concentration range.