Integrative microRNA and gene expression analysis identifies new drug repurposing candidates for fetal hemoglobin induction in β-hemoglobinopathies
2019
Abstract Therapeutic
inductionof
fetal hemoglobin(HbF) is one of the most promising approaches to ameliorate the severity of
hemoglobinopathieslike β-thalassemia and
sickle cell anemia. Although several pharmacological agents have been investigated for HbF
inductionin adults, the majority of these are associated with significant side-effects. While drug
repurposingis known to open new doors for the use of
approved drugsin unexplored clinical conditions, the primary challenge lies in identifying such candidates. In this study, we aimed to identify
repurposingcandidates for HbF
inductionusing a novel in silico approach utilizing microRNA-pathway-drug relationships. A computational drug
repurposingstrategy identified several unique candidates for HbF
induction; among which Curcumin,
Ginsenoside, Valproate, and
Vorinostatwere found to be most suitable for future trials. This study identified new drug
repurposingcandidates for HbF
inductionand demonstrates an easily adaptable methodology that can be used for other pathophysiological conditions.
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