Objective quantification of BCL2 protein by multiplex immunofluorescence in routine biopsy samples of diffuse large B-cell lymphoma demonstrates associations with survival and BCL2 gene alterations

Lina Chen,Kathrin Tyryshkin,Alison M. Moore,David W. Scott,Christian Steidl,Yi Li,Lois E. Shepherd,Michael J. Rauh,Lan Deng,David Good,Shakeel Virk,Bingshu E. Chen,Susan Crocker,Tara Baetz,David P. LeBrun

Objective quantification of BCL2 protein by multiplex immunofluorescence in routine biopsy samples of diffuse large B-cell lymphoma demonstrates associations with survival and BCL2 gene alterations

2020

Lina Chen
Kathrin Tyryshkin
Alison M. Moore
David W. Scott
Christian Steidl
Yi Li
Lois E. Shepherd
Michael J. Rauh
Lan Deng
David Good
Shakeel Virk
Bingshu E. Chen
Susan Crocker
Tara Baetz
David P. LeBrun

AbstractUp-regulation of BCL2 in cases of diffuse large B-cell lymphoma (DLBCL) can confer treatment resistance. Quantitative immunofluorescence (QIF) histology allows objective quantification of p...

Keywords:

Immunology
Diffuse large B-cell lymphoma
Biopsy
Immunofluorescence
Multiplex
Diabetes mellitus
Gene
Pathology
Medicine
Biomarker (medicine)
Lymphoma
Histology

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