Whole-Blood miRNA Sequencing Profiling for Vasospasm in Patients With Aneurysmal Subarachnoid Hemorrhage
2018
Background and Purpose— Arterial
vasospasmis a well-known delayed complication of aneurysmal subarachnoid hemorrhage (aSAH). However, no validated biomarker exists to help clinicians discriminating patients with aSAH who will develop
vasospasm(VSP+) and identifying those who then deserve aggressive preventive therapy. We hypothesized that
whole-bloodmiRNAs could be a source of candidate biomarkers for
vasospasm. Methods— Using a next-generation sequencing approach, we performed
whole-bloodmiRNA profiling between VSP+patients with aSAH and patients who did not develop
vasospasm(VSP−) in a prospective cohort of 32 patients. Profiling was performed on the admission day and 3 days before
vasospasm. Results— Four hundred forty-two miRNAs were highly expressed in
whole bloodof patients with aSAH. Among them, hsa-miR-3177-3p demonstrated significant (P=5.9×10−5; PBonferroni corrected=0.03) lower levels in VSP− compared with VSP+ patients. Looking for
whole-bloodmRNA correlates of hsa-miR-3177-3p, we obser...
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