Detection of NRAS mutation in cell-free DNA biological fluids from patients with kaposiform lymphangiomatosis

Background Kaposiform lymphangiomatosis(KLA) has recently been distinguished as a novel subtype of generalized lymphatic anomaly (GLA) with foci of spindle endothelial cells. All casesof KLA involve multiple organs and have an unfavorable prognosis. However, the molecular pathogenesis is unknown, and there are no useful biomarkers. In the present study, we performed genetic analysisto elucidate the cause of this disease and detect biomarkers for it.