Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017

We report a multidrug- resistant Neisseria gonorrhoeaeurogenital and pharyngealinfection with ceftriaxone resistanceand intermediate resistanceto azithromycinin a heterosexualwoman in her 20s in France. Treatment with ceftriaxoneplus doxycyclinefailed for the pharyngeallocalisation. Whole-genome sequencingof isolate F90 identified MLST1903, NG-MAST ST3435, NG-STAR233, and relevant resistancedeterminants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug- resistantand ceftriaxone- resistantclone detected in Japan and subsequently in Australia, Canada and Denmark.