ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

Poly(ADP-ribose) polymerasesparticipate in many biological and pathological processes. Takaoka and co-workers show that the short isoform of PARP-13 (ZAPS) is selectively induced by 5'-triphosphate–modified RNA and regulates signaling mediated by the RNA helicase RIG-I.