Prevalence of Early B-Cell Factor 1 Gene rs4704963 Single Nucleotide Polymorphism (T>C) in a Population of Type 2 Diabetic Patients with Obesity

espanolIntroduccion: En estudios previos, se determino para una poblacion con agravamiento de la diabetes tipo 2 con obesidad(DBT+Ob) que sufria estres una prevalencia del polimorfismo de nucleotido unico ( SNP) rs4704963 (T > C) del gen EarlyB-Cell Factor 1 (EBF1) del 16,5%.Objetivos: Determinar la prevalencia de este SNPen pacientes con DBT+ Ob que acuden al Hospital Ramos Mejia de la CiudadAutonoma de Buenos .Aires y establecer si dicho polimorfismo se asocia con el estres o la ocurrencia de eventos coronariosagudos.Material y metodos: Se llevo a cabo un estudio observacional, prospectivo, sobre prevalencia del polimorfismo en 53 pacientescon DBT+Ob e indice de masa corporal (IMC) entre 28 y 41, atendidos en el citado hospital en un periodo de 15 meses. Acadapaciente se le computo una escala de estres percibido, ademas de evaluarlo mediante la escala de acontecimientos vitalesestresantes.Para el analisis estadistico, se realizaron las pruebas de Chi cuadrado y se calcularon los odds ratio (OR).Resultados: La poblacion evaluada (53 pacientes) tuvo una media de edad de 60,2 ±9,77 anos; 47,2% fueron hombres. De ellos,8 individuos (15,1%) presentaron el SNPy todos fueron heterocigotas. Quince sujetos (28,3%) tuvieron sindrome isquemicoagudo (SIA) y de estos solo uno (6,6%) tenia el SNP. No se hallo relacion estadisticamente significativa entre la presencia delSNP y la aparicion de SIA (p = 0,282). Catorce pacientes (26,4%) presentaron estres cronico moderado o grave, y no huborelacion entre este hallazgo y la presencia del SNP(p = 0,979).Conclusiones: La prevalencia del SNPrs4704963 (T > C) del gen EBF1 en la poblacion de DBT+Ob estudiada fue del 15,1%y no se hallo relacion estadisticamente significativa del SNPcon el estres ni con el SIA. EnglishBackground: Previous studies established that in a population with exacerbation of type 2 diabetes with obesity (DBT+Ob)suffering from stress, the prevalence of early B-Cell Factor 1 (EBF1) gene rs4704963 single nucleotide polymorphism ( SNP)(T>C) is 16.5%.Objectives: The aim of this study was to determine the prevalence of this SNPin patients with DBT+Ob attending HospitalRamos Mejia of the Autonomous City of Buenos Aires and to ascertain whether this polymorphism is associated with stressor acute coronary events.Methods: An observational, prospective study on the prevalence of rs4704963 SNPwas performed in 53 patients with DBT+Oband body mass index between 28 and 41, seen in Hospital Ramos Mejia for a period of 15 months. Each patient was evaluatedwith a stressful life events scale and a perceived stress scale.The chi-square test and odds ratio (OR) were used for statistical analysis.Results: A total of 53 patients were included in the study. Mean population age was 60.2±9.77 years and 47.2% were men.Among these patients, 8 (15.1%) presented SNPand all were heterozygous. Fifteen patients (28.3%) had acute ischemicsyndrome (AIS), and among these, only one (6.6%) had SNP. No statistically significant relationship was found between thepresence of SNPand AIS (p=0.282). Fourteen patients (26.4%) presented moderate or severe chronic stress, and there wasno relationship between this finding and the presence of SNP(p=0.979).Conclusions: The prevalence of EBF1 gene rs4704963 SNP(T>C) in the DBT+Ob population was 15.1%. No statisticallysignificant association was found between SNPand stress or AIS.