Evaluation of microcirculation before and during continuous renal replacement therapy and the impact of dose prescription

Microcirculation (MC) might provide evidence for the solute exchange taking place during the dialysis process. Near-infrared spectroscopy (NIRS) with combination of vascular occlusion technique (VOT) allows evaluation of peripheral tissue oxygen utilization and restoration mainly depending on integrity and functionality of vascular endothelium. Our purpose was to evaluate the acute effect of continuous renal replacement therapy (CRRT) on the MC as assessed by NIRS and VOT and to explore the impact of delivered CRRT dose on MC alterations.