Efficacy of Omadacycline Against Escherichia coli in a Mouse UTI Model.

In a mouse urinary tract infection model, omadacycline (OMC) was comparable to gentamicin and better than ciprofloxacin (CIP) against a tetracycline (TET) susceptible, CIP-R Escherichia coli strain. Gentamicin showed better efficacy than OMC against a TET-R, CIP-R E. coli strain and OMC again showed better efficacy than CIP against this strain. OMC may warrant further study as a potential option for UTI treatment against CIP-R E. coli strains.