Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy

Highlights •Endomyocardial biopsy obtained from patients with new onset heart failure. •Patients are followed long-term to determine clinical outcome and prognosis. •Total RNA is purified from the endomyocardial biopsy specimen and subjected to microarray analysis. •Pathway discovery and development of transcriptomic biomarkers are determined that predict clinical response to beta-adrenergic antagonists.