A computerized, self-administered test of verbal episodic memory in elderly patients with mild cognitive impairment and healthy participants: A randomized, crossover, validation study

Abstract Introduction Performance of “ Revere”, a novel iPad-administered word-list recall (WLR) test, in quantifying deficits in verbal episodic memory, was evaluated versus examiner-administered Rey Auditory Verbal Learning Test (RAVLT) in patients with mild cognitive impairment and cognitively normal participants. Methods Elderly patients with clinically diagnosed mild cognitive impairment ( Montreal Cognitive Assessmentscore 24–27) and cognitively normal ( Montreal Cognitive Assessmentscore ≥28) were administered RAVLT or Reverein a randomized crossover design. Results A total of 153/161 participants ( Revere/RAVLT n = 75; RAVLT/ Reveren = 78) were randomized; 148 (97%) completed study; 121 patients (mean [standard deviation] age: 70.4 [7.84] years) were included for analysis. Word-list recall scores (8 trials) were comparable between Revereand RAVLT (Pearson's correlation coefficients: 0.12–0.70; least square mean difference [ Revere-RAVLT]: −0.84 [90% CI, −1.15; −0.54]). Model factor estimates indicated trial ( P P P = .038) as significant factors. Learning over trials index and serial position effectswere comparable. Discussion Participants' verbal recall performance on Revereand RAVLT were equivalent.