The toll-like receptor 4 agonist MRP8/14 protein complex (calprotectin) in autoinflammation: potential biomarker in chronic nonbacterial osteomyelitis – a case report

The cytoplasmic S100 proteinsderived from cells of myeloid origin. Calprotectin(MRP8/14 protein complex) might be a biomarker either for autoinflammation and autoimmunopathy. Since autoinflammatory diseases might be a diagnostic challenge calprotectinmay be helpful in the diagnosis of autoinflammatory diseases. Chronic nonbacterial osteomyelitis(CNO) is an autoinflammatory, noninfectious disease. CNO describes a wide spectrum from a monofocal bone lesion to the chronic recurring multifocal osteomyelitis(CRMO). Laboratory and histopathological findings are nonspecific. In some patients systemic inflammatory signs such as elevated acute phase proteinscannot be found.