Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline

Although an association between high blood pressureand cognitive declinehas been reported, no studies have investigated the association between home blood pressureand cognitive decline. Home blood pressuremeasurements can also provide day-to-day blood pressurevariability calculated as the within-participant SD. The objectives of this prospective study were to clarify whether home blood pressurehas a stronger predictive powerfor cognitive declinethan conventional blood pressureand to compare the predictive powerof the averaged home blood pressurewith day-to-day home blood pressurevariability for cognitive decline. Of 485 participants (mean age, 63 years) who did not have cognitive decline(defined as Mini-Mental State Examinationscore, <24) initially, 46 developed cognitive declineafter a median follow-upof 7.8 years. Each 1-SD increase in the home systolic blood pressurevalue showed a significant association with cognitive decline(odds ratio, 1.48; P=0.03). However, conventional systolic ...