Increases in Waist Circumference and Weight As Predictors of Type 2 Diabetes in Individuals With Impaired Fasting Glucose: Influence of Baseline BMI: Data from the DESIR study

Abstract Objective— To evaluate in impaired fasting glucose (IFG), the relative importance of increases in waist circumference and weight on progression to type 2 diabetes. Research design and methods— The 9-year incidence of diabetes was studied in 979 men and women with baseline IFG, from the D.E.S.I.R. cohort. Results— Increases in both waist circumference and weight were significantly associated with diabetes incidence, standardized ORs (95%CI): 1.79 (1.45-2.21) and 1.86 (1.51-2.30) respectively, after controlling for baseline risk factors. The impact of waist circumference increase was greater for BMI 2 : 2.40 (1.63-3.52) than for BMI≥25 kg/m 2 : 1.66 (1.28-2.16) and persisted after adjusting for concurrent changes in either insulinemia or the HOMA2-IR index. Weight change had a similar impact in both BMI groups. Conclusions— In IFG individuals, it is important to monitor and prevent increases in waist circumference, in particular for those with BMI 2 .