Cofilin Oligomer Formation Occurs In Vivo and Is Regulated by Cofilin Phosphorylation

Background ADF/ cofilinproteins are key regulators of actindynamics. Their function is inhibited by LIMK-mediated phosphorylation at Ser-3. Previous in vitro studies have shown that dependent on its concentration, cofilineither depolymerizesF- actin(at low cofilinconcentrations) or promotes actinpolymerization (at high cofilinconcentrations).