Chronic sequelae and severe complications of norovirus infection: A systematic review of literature.
2018
Abstract
Noroviruscauses an estimated 18% of all cases of acute gastroenteritis worldwide and is found to be associated with mortality. To create a first overview of severe complications and chronic
sequelaeof
norovirusinfections, a systematic review of literature was performed. Of 3928 individual hits, 176 publications remained for data extraction. Study periods varied between 1974 and 2017, though strongly skewed towards the last decade (n = 122, 70%). Countries of studies were worldwide, though Africa, and Carribean, Central and South America were underrepresented. Strong evidence was found for
chronic diarrheain immunocompromised patients, affecting 9%–100% of investigated cohorts. The duration of
chronic diarrheavaried from four weeks up to nine years, leading to either wasting, weight loss or
failureto
thrivein a third of the reported cases (224). Other complications with significant evidence were
necrotizing enterocolitis(NEC) in preterm infants associated with
norovirusinfection (8 papers), and benign infantile convulsions with gastroenteritis (BICG; 19 papers). Studies on
norovirusinfection and inflammatory bowel disease (IBD) mostly concluded against this association (5 of 7). The remaining papers mentioned a large variety of possible
sequelaeor complications. Based on the available literature, chronic
norovirusdiarrhea is the major
sequelaof
norovirusinfection in primary immune deficient, oncologic and transplant patients.
Norovirusinfection – like other gastrointestinal pathogens – can cause a range of
sequelaeand complications, and should be considered in the differential diagnosis of these manifestations.
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