Modulation of muscle protein synthesis by amino acids: what consequences for the secretome? A preliminary in vitro study
2019
The modulation by
amino acidsof muscle
secretomeis largely unknown. In this study, we investigate the effect of
hyperaminoacidemiaor specific
amino acids(
citrullineor leucine) on protein synthesis and
secretomein myotubes. All conditions stimulate muscle protein synthesis, and
secretomeis differently modulated depending of the
amino acidsconsidered. In conclusion, the activation of protein synthesis by
amino acidsinduces different modulations of the muscle
secretome, proposing a new role of
amino acidsin the regulation of muscle function.
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