DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL -rearranged leukemia

Chun-Wei Chen,Richard Koche,Amit U. Sinha,Aniruddha Deshpande,Nan Zhu,Rowena Eng,John G. Doench,Haiming Xu,Scott H. Chu,Jun Qi,Xi Wang,Christopher Delaney,Kathrin M. Bernt,David E. Root,William C. Hahn,James E. Bradner,Scott A. Armstrong

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL -rearranged leukemia

2015

Chun-Wei Chen
Richard Koche
Amit U. Sinha
Aniruddha Deshpande
Nan Zhu
Rowena Eng
John G. Doench
Haiming Xu
Scott H. Chu
Jun Qi
Xi Wang
Christopher Delaney
Kathrin M. Bernt
David E. Root
William C. Hahn
James E. Bradner
Scott A. Armstrong

The authors uncover the mechanism by which DOTL1 exertsits role as an epigenetic regulator required for leukemic progression by counteracting the effects of the chromatin regulators SIRT1 and SUV39H1.

Keywords:

Gene silencing
Myeloid-Lymphoid Leukemia Protein
Chromatin remodeling
Epigenomics
DOT1L
Chromatin
Cancer research
Cancer epigenetics
Biology
Bivalent chromatin
gene rearrangement

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