Hepatic Arterial Infusion of Paclitaxel for Liver Metastasis from Gastric Cancer

Little is known about hepatic arterial infusion( HAI) of paclitaxelfor hepatic malignancies. The authors administered paclitaxelvia the HAIport in two patients with liver metastases from gastric cancer. Both patients were uneventfully treated without any serious complications, and its anti-tumor effect on 5-fluouracil resistant liver metastases was confirmed. However, the kinetics of venous paclitaxelconcentration following HAIwas similar to that after intravenous injection. Our findings did not support the advantage of paclitaxel HAItherapy, although HAIof this agent was well tolerated.