Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation

Li Yu, Ya-Ping Zhang, Chung-I Wu and colleagues report the de novo genome of the black snub-nosed monkeyRhinopithecus bieti and the genomic sequences of four other Rhinopithecus species, including three high- altitudeand two lowland species. The species- and population-level genomic analyses as well as the transcriptomicanalysis and functional assays find adaptive signatures associated with adaptation to high altitude.