Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia
2006
The e4 allele of the
apolipoprotein Egene (APOE4) has been consistently associated with a greater risk of Alzheimer's disease (AD) as well as an earlier onset of AD. It is possible that APOE4 may also play a role in the etiology of other neurodegenerative disorders, such as Parkinson's disease (PD). APOE genotype,
ageof
onset, disease duration, smoking history, and dementia status were collected for families with PD, yielding 324 Caucasian families with
complete information.
Logisticregression employing one individual per family and including
ageof
onsetand disease duration as covariates demonstrated a significantly increased risk of dementia for those individuals having inherited at least one e4 allele (OR = 3.37; P = 0.002). Survival analyses also demonstrated a significantly earlier
ageof
onsetfor those subjects with at least one e4 allele (59.7 years) as compared with those homozygous for the more common e3 allele (62.4 years; P = 0.009). Thus, consistent with previous studies, we find evidence that the presence of an e4 allele results in significantly earlier onset of PD and a greater likelihood of dementia. It appears the similarities between PD and AD may be due to an overlap in the diseases' genetic etiology. © 2005 Movement Disorder Society
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