Successful therapy of plaque-type psoriasis with secukinumab in patients with multiple comorbidities treated with previous biologic therapies

AbstractPurpose: Biologic therapy in psoriatic patients with multiplecomorbidities is challenging due to worsening of associated diseases and possible side effects of concomitant medications.Materials and methods: We describe three patients with multiplecomorbidities documenting successful treatment of psoriasis with secukinumabfollowing failure of multipleconventional and biologic DMARDs.Results: The first case is an obese 59-year-old woman (HBV + with latent tuberculosis) with arterial hypertension and 12-year history of breast cancer. The second is a 45-year-old obese man (HCV + with occult HBV infection on therapy with multipleantipsychotics and taking methadonefor opioid dependence), while the last is a 39-year-old man with severe obesity, non-alcoholic hepatosteatosis, and NYHA class II heart failure. All three patients had undergone previous conventional (methotrexate, cyclosporine, retinoidsand phototherapy) and multiplebiologic treatments (one or more of the following: adalimumab, ustekin...