Emergence of Zebrafish as a Model System for Understanding Human Scoliosis
2018
Scoliosisis a three-dimensional rotation of the spine that is defined as lateral curvature with a
Cobb anglegreater than 10 degrees. About 2–3% of the global population is affected by
scoliosis, and more than 80% of
scoliosisare caused by unknown factors (idiopathic). Adolescent idiopathic
scoliosisis the most common type of
scoliosisand occurs in children over 10 years, showing a female predominance. Of
scoliosispatients, 10% have curve progression requiring medical interventions such as bracing and surgery.
Scoliosisresearch has been delayed due to the genetic complexity and a lack of relevant animal models for functional studies; however, significant breakthroughs of
scoliosisstudy have recently been made using zebrafish. The zebrafish is a powerful tool, owing to easy genetic manipulation and a natural susceptibility to spinal curvature. Here, we summarize the utility of zebrafish as a model system for human
scoliosis.
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