Anp32E is a Histone Chaperone that Removes H2A.Z from Chromatin

The histoneH2A.Z is a variant of histone H2A, one of the canonical histonespresent in the chromatin of eukaryotic cells. H2A.Z has important functions in transcription and other nuclear processes. Here, Ali Hamiche and colleagues identify the human protein ANP32E as an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin. Biochemical and structural data indicate the molecular basis for H2A.Z recognition and evictionby ANP32E, and genome-wide mapping analyses reveal how ANP32E regulates H2A.Z occupancy at important regulatory regions of the genome.