Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K+ Channel–Related Acid-Sensitive K+ Channel-1) (K2P3.1) K+ Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling

Constanze Schmidt,Felix Wiedmann,Christoph Beyersdorf,Zhihan Zhao,Ibrahim El-Battrawy,Huan Lan,Gábor Szabó,Xin Li,Siegfried Lang,Sevil Korkmaz-Icöz,Kleopatra Rapti,Andreas Jungmann,Antonius Ratte,Oliver J Müller,Matthias Karck,Gunnar Seemann,Ibrahim Akin,Martin Borggrefe,Xiaobo Zhou,Hugo A. Katus,Dierk Thomas

Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K+ Channel–Related Acid-Sensitive K+ Channel-1) (K2P3.1) K+ Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling

2019

Background: Despite an increasing understanding of atrial fibrillation (AF) pathophysiology, translation into mechanism-based treatment options is lacking. In atrial cardiomyocytes of patients with...

Keywords:

Atrial fibrillation
Electrical Remodeling
Pathophysiology
Catheter ablation
Cardiology
Internal medicine
Medicine
Ablation
k channels
genetic ablation
treatment options
acid sensitive

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