A 10 ps Time-Resolution CMOS Image Sensor With Two-Tap True-CDS Lock-In Pixels for Fluorescence Lifetime Imaging
2016
A CMOS lock-in pixel
image sensorwith embedded storage diodes and lateral electric field modulation (LEFM) of photo-generated charge is developed for fluorescence lifetime imaging. The time-resolved CMOS
image sensor(CIS) with two-tap lock-in pixels achieves a very high time resolution of 10 ps when images are averaged over 30 frames, a very short intrinsic response time of 180 ps at 374 nm, and a low temporal random noise of $1.75{\text{
e}}^{-}_{\
text{rms}}$ with true
correlated double sampling(CDS) operation. In addition, by using the LEFM and optimized process, a very high
extinction ratioof approximately 94% at 472 nm laser diode is achieved. The usefulness of the proposed CIS is demonstrated for fluorescence lifetime imaging with the simulation and measurement results.
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