Abstract 16939: Association of Change in BMI From Early Adulthood to Middle Age With Left Atrial Structure and Function by Three-dimension Speckle Tracking Echocardiography: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Background: Longstanding obesity is associated with impaired left ventricle (LV) systolic and diastolic function evaluated by two-dimension echocardiography. Left atrial (LA) remodeling is a prognostic marker for cardiovascular (CV) diseases including heart failure, atrial fibrillation, and stroke. Three-dimensional echocardiography (3DE) allows a more reproducible, and detailed evaluation of cardiac structure and function. Hypotheses: Increases in body mass index (BMI) from early adulthood to middle age will be associated with adverse left atrial (LA) remodeling evaluated by 3DE. Methods: CARDIA is a cohort study that enrolled black and white adults (18-30 years) from 4 US Fields Centers beginning in 1985-1986. Participants who underwent 3DE (Artida Echo System, Toshiba) in the CARDIA Year-30 examination and with BMI measurements during the study follow-up were included in this study (n=1,160). 3DE LA measurements were obtained using a wall motion tracking software (figure). Average percent change in BMI...