EVALUATION OF DYSFUNCTION IN BLOOD COAGULATION IN CHILDREN WITH URTICARIA

Recently, an association between coagulation dysfunction and the pathology of urticaria has been reported, but research in children is scarce.We measured levels of prothrombin fragments 1+2 (PTF1+2), fibrin degradation product (FDP), D-dimer, and mean platelet volume (MPV) in 32 children with urticaria. The study cohort comprised 18 cases of chronic and active urticaria, 7 cases of chronic and inactive urticaria, and 7 cases of acute urticaria.PTF1+2 levels in the chronic and active urticaria group were higher than those in the chronic and inactive urticaria group (p<0.01). PTF1+2 levels in the acute urticaria group were higher than those in the chronic and inactive group (p<0.05). No significant difference was observed in the levels of FDP, D-dimer, and MPV among the three groups of the patients. Levels of PTF1+2, FDP, and D-dimer decreased as symptoms improved.Plasma levels of PTF1+2 may be useful for assessment of the activity of urticaria.