From Primary Hypergonadotropic Amenorrhea to “POI”: Aetiology and Therapy

Premature ovarian damage with onset before menarche is expressed clinically with primary hypergonadotropic amenorrhea. The term premature ovarian insufficiency (POI) currently used in the literature worldwide substitutes the previously used POF (premature ovarian failure). The very concept of POI refers to the many, varied clinical expressions of ovarian insufficiency, including the possible albeit usually transitory recuperation of ovarian function.