Bariatric Surgery Rapidly Decreases Cardiac Dietary Fatty Acid Partitioning and Hepatic Insulin Resistance Through Increased Intra-abdominal Adipose Tissue Storage and Reduced Spillover in Type 2 Diabetes

Reduced storage of dietary fatty acids (DFA) in abdominal adipose tissues with their enhanced cardiac partitioning has been shown in subjects with type 2 diabetes (T2D) and pre-diabetes. We measured DFA metabolism and organ partitioning using positron-emission-tomography with oral and i.v.long-chain fatty acid and glucose tracers during a standard liquid meal in 12 obese subjects with T2D prior to and 8 to 12 days after bariatric surgery (sleeve gastrectomy and biliopancreatic diversion). Bariatric surgery reduced cardiac DFA uptake (from 1.75 [1.39-2.57] (median [interquartile range]) before to 1.09 [1.04-1.53] standard uptake value (SUV) after surgery, P