SYNTHESIS OF HETEROARYL-FUSED PYRAZOLES AS P38 KINASE INHIBITORS

Kristen Lynn Mccaleb,Sarah C. Abbot,Roland Joseph Billedeau,Nolan James Dewdney,Tobias Gabriel,David Michael Goldstein,Michael Soth,Teresa Alejandra Trejo-Martin,Hasim Zecic

SYNTHESIS OF HETEROARYL-FUSED PYRAZOLES AS P38 KINASE INHIBITORS

2009

Kristen Lynn Mccaleb
Sarah C. Abbot
Roland Joseph Billedeau
Nolan James Dewdney
Tobias Gabriel
David Michael Goldstein
Michael Soth
Teresa Alejandra Trejo-Martin
Hasim Zecic

The synthesis of pyrazolo-pyridine, pyrimidine, pyrazine and pyridazine heterocycles is described. In addition, we report the utilization of 2,4-difluorophenoxide as a leaving group, to facilitate formation of the desired pyrazole adducts.

Keywords:

Pyrimidine
Leaving group
Pyrazole
Pyrazolopyridine
Pyrazolopyrimidine
Pyrazine
Adduct
Organic chemistry
Pyridazine
Biochemistry
Chemistry
p38 mitogen-activated protein kinases

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations