A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode

Vineet Pande,Weimei Sun,Lijs Beke,Didier Jean-Claude Berthelot,Dirk Brehmer,David G. Pfizer Global Res. Dev. Brown,Jordi Corbera,Steve Irving,Lieven Meerpoel,Thomas Nys,Marc Parade,Colin M. Pfizer Global Res. Dev. Robinson,Cois Sommen,Marcel Viellevoye,Tongfei Wu,Jan Willem Thuring

A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode

2020

Vineet Pande
Weimei Sun
Lijs Beke
Didier Jean-Claude Berthelot
Dirk Brehmer
David G. Pfizer Global Res. Dev. Brown
Jordi Corbera
Steve Irving
Lieven Meerpoel
Thomas Nys
Marc Parade
Colin M. Pfizer Global Res. Dev. Robinson
Cois Sommen
Marcel Viellevoye
Tongfei Wu
Jan Willem Thuring

Protein arginine methyltransferase 5 (PRMT5) is an enzyme that can symmetrically dimethylate arginine residues in histones and nonhistone proteins by using S-adenosyl methionine (SAM) as the methyl...

Keywords:

Histone
Protein arginine methyltransferase 5
Chemical probe
Methionine
Chemistry
Non-histone protein
Methyltransferase
Biochemistry
Enzyme
Arginine

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