Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
2016
Very few genetic variants have been
associatedwith depression and
neuroticism, likely because of limitations on sample size in previous studies.
Subjective well-being, a
phenotypethat is
genetically correlatedwith both of these traits, has not yet been studied with genome-wide data. We conducted
genome-wide association studiesof three
phenotypes:
subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and
neuroticism(n = 170,911). We identify 3 variants
associatedwith
subjective well-being, 2 variants
associatedwith depressive symptoms, and 11 variants
associatedwith
neuroticism, including 2 inversion polymorphisms. The two loci
associatedwith depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high
genetic correlationsbetween the
phenotypes(|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our
phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for
association.
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