Early antithrombotic treatment with warfarin oral suspension in severe neonatal protein C deficiency

Summary Neonatal severe protein C deficiencyis a serious disease. There is no uniform approach for long-term preventive treatmentof thrombotic events. We report the case of neonatal severe protein C deficiencytreated with warfarin oral suspension. An international normalized ratio (INR) from 2.5 to 3.5 was expected. The INR was measured by home monitoring using the Coaguchek XS ® ( Roche Diagnostics, Mannheim, Germany) monitor. During 2 years of warfarin treatment, there were only two minor episodes of purpuric access and no bleeding was reported. This case suggests that the early introduction of warfarin oral suspension, home-care monitoring, and parental education programs may be a beneficial treatment option for children with protein C deficiency.