Neuroimaging studies in people at clinical high risk for psychosis

Abstract In neuroimaging studies of people at clinical high risk (CHR) for psychosis, it is possible to assess the structure, function, connectivity, and chemistry of the brain before, during, and after the onset of a psychotic disorder. This chapter describes the range of neuroimaging techniques that have been applied to CHR populations and discusses current limitations and future directions. We highlight the need for both multicenter collaboration in recruitment of CHR participants and for standardized methods to allow the aggregation of data from separate CHR cohorts. Of particular interest in neuroimaging of psychosis risk is the application of machine learning–based classifiers, which could be used in providing individualized treatment.