Regulation of Adrenocortical Function by the Sympathoadrenal System

In the first complete description of the adrenal gland in 1852, von Kolliker described the adrenal as composed of two different tissues, with the cortex belonging to the “blood-vascular glands” and the medulla, a part of the nervous system, resembling a ganglion (1). The astonishing arrangement of these two tissues justifies the question: What is a ganglion doing inside a gland (2)?