Risk Factors Party Together: The Role of Perineural Invasion and Desmoplasia in Cutaneous Squamous Cell Carcinoma Prognosis.

In the current issue, Haug et al. 2020 report on the prognostic impact of perineural invasion (PNI) and desmoplasia on cutaneous squamous cell carcinoma (CSCC) recurrence and metastasis. They find that PNI occurs exclusively in desmoplastic CSCC, and desmoplasia is independently associated with CSCC recurrence and metastasis after adjusting for well-established CSCC risk factors. Future studies should assess the contribution of desmoplasia in CSCC prognosis.