Biallelic mutations in DYNC2LI1 are a rare cause of Ellis-van Creveld syndrome
2018
Ellis van Creveld syndrome(EvC) is a chondral and
ectodermal dysplasiacaused by biallelic mutations in the EVC, EVC2 and WDR35 genes. A proportion of cases with clinical diagnosis of EvC, however, do not carry mutations in these genes. To identify the genetic cause of EvC in a cohort of mutation-negative patients,
exome sequencingwas undertaken in a family with three affected members, and mutation scanning of a panel of clinically and functionally relevant genes was performed in 24 additional subjects with features fitting/overlapping EvC.
Compound heterozygosityfor the c.2T>C (p.Met1?) and c.662C>T (p.Thr221Ile) variants in DYNC2LI1, which encodes a component of the
intraflagellar transport-related
dynein-2 complex previously found mutated in other
short-ribthoracic dysplasias, was identified in the three affected members of the first family. Targeted resequencing detected
compound heterozygosityfor the same missense variant and a frameshift change (p.Val141*) in two siblings with EvC from a second family, while a newborn with a more severe phenotype carried two DYNC2LI1 truncating variants. Our findings indicate that DYNC2LI1 mutations are associated with a wider clinical spectrum than previously appreciated, including EvC, with the severity of the phenotype likely depending on the extent of defective DYNC2LI1 function.
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