A systematic literature review comparing methods for the measurement of patient persistence and adherence
2018
AbstractObjectives: A systematic literature review was conducted comparing different approaches estimating persistence and adherence in chronic diseases with
polypharmacyof oral and subcutaneous treatments.Methods: This work followed published guidance on performing systematic reviews. Twelve electronic databases and
grey literaturesources were used to identify studies and guidelines for persistence and adherence of oral and subcutaneous therapies in hypercholesterolemia, type 2 diabetes, hypertension, osteoporosis and rheumatoid arthritis. Outcomes of interest of each persistence and adherence data collection and calculation method included pros: accurate, easy to use, inexpensive; and cons: inaccurate, difficult to use, expensive.Results: A total of 4158 records were retrieved up to March 2017. We included 16 observational studies, 5 systematic reviews and 7 guidelines, in patients with hypercholesterolemia (n = 8), type 2 diabetes (n = 4), hypertension (n = 2), rheumatoid arthritis (n = 1) and mixed ...
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