Time serial development of optical performance of the myopic model mouse eyes

Myopia is a significant cause of visual impairment which may lead to many complications. Though the mechanism of myopia is not clear, the changes of the biological parameters and the optical performance of eyes were suggested as a key mechanism. In order to investigate the mechanism of myopia, in this paper, the time serial evaluation of biological parameters was performed and the optical performance of myopic model mouse eyes were evaluated by using optical coherence tomography (OCT) and ZEMAX software. The biological parameters were compared, and the optical performance of mouse eyes were evaluated in the myopic model mouse eyes, normal control mouse eyes and atropine-treated mouse eyes. The correlation analysis of the statistics indicated that the development of myopia was significantly related to the corneal curvature radius, center corneal thickness, vitreous depth and axial length (P<0.05). The analysis of biological parameters proved that the peripheral RMS wavefront aberration of eyes played more crucial roles in the development of myopia than the center parameters, and the degree of myopia would be proofed by the hyperopic wavefront aberration. The myopic model mouse eyes had larger corneal curvature radius, thicker center corneal thickness, deeper vitreous depth and longer axial length than normal mouse eyes. The experimental results of atropine-treated eyes suggested that atropine could relieve myopia and eye enlargement via a nonaccommodative mechanism. This study provides a new method for evaluations of the optical performance of eyes and the study of myopia.