A study of features of the inheritance of latent autoimmune diabetes of adults (LADA)

A study of the genetic determinationof latent autoimmune diabetesof adults(LADA) is conducted on data consistingof clinical and genealogical data on 51 patients with LADA, 400 patients with insulin-dependent diabetes mellitus( type 1 diabetesmellitus), and 504 patients with insulin-independent diabetes mellitus( type 2 diabetesmellitus), along with relatives of these patients (first degree of consanguinity). Testing of the Smith model revealed the genetic independence of LADA and both type 1 and type 2 diabetesmellitus. A study of genetic heterogeneity in accordance with the Smith model showed that LADA shares roughly the same number of common genes with type 1 diabetesmellitus and with type 2 diabetesmellitus, which also determines the clinical course of this form of diabetes. The inheritance of LADA is described by parameters of a polygenic threshold model. Within the framework of this model, it is found that genetic factors are responsible for 60.4% of the development of the disease.