Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

Substantial risk for schizophreniais conferred by large copy number variants at a number of genomic loci. Here, a significant association between duplications on chromosome 7 and schizophreniais reported. Importantly, microduplication analysis narrowed down the region to a region just upstream of a gene encoding vasoactive intestinal peptide receptor( VIPR2). Increased expression of VIPR2in patients with schizophreniaimplicates VIP signalling as a molecular mechanismunderlying schizophrenia.