National patterns of care for early-stage penile cancers in the United States: How is radiation and brachytherapy utilized?
2019
Abstract Purpose Per American
BrachytherapySociety guidelines, cT1-2N0
penile cancersMethods and Materials The National Cancer Database was queried for men with cT1-2N0
penile cancersResults Among 1235 cases eligible for analysis, median age was 69 years. Median tumor size was 2.0 cm. 95.8% of men underwent surgery alone, with 91 (7.4%) undergoing radical
penectomy, 673 (54.5%) partial
penectomy, and 419 (33.9%)
cosmesis-preserving surgical procedure. Only 4 (0.3%) men were treated with
brachytherapyalone, 48 (3.9%) with external-beam radiation therapy (EBRT) alone, and 8 (0.6%) with EBRT after surgery.
Surgical marginswere positive in 118 (9.6%) patients, 14 of whom received adjuvant EBRT (11.9%) and two adjuvant
brachytherapy(1.7%). There was no difference in demographic or clinical characteristics in groups treated with surgery vs. radiation (all p > 0.2). Age >70, lesions >2 cm, and T2 tumors were more likely to undergo non–organ-preserving therapy vs. radiation or a
cosmesis-preserving procedure (all p p = 0.70). Conclusions Men with penile-preserving eligible lesions in the United States are overwhelmingly treated with surgery. Penile-preserving radiation techniques including
brachytherapyand EBRT are underutilized and should be offered as curative interventions.
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