PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
2016
The
adrenal cortexundergoes functional zonation to generate an outer
zona glomerulosa(ZG) and inner
zona fasciculata(ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
-
Machine Reading By IdeaReader
50
References
57
Citations
NaN
KQI