Nitric oxide and reactive species are modulated in the polyphenol-induced ductus arteriosus constriction in pregnant sheep
2014
Objective Because we have previously demonstrated the relation between
polyphenol-rich foods (PRF) consumption and
ductus arteriosus
constriction, in this work, pregnant sheep were submitted to oral PRF intake for 14days to understand how this process occurs. Fetal
Doppler echocardiography, oxidative and inflammatory biomarkers and total
polyphenolexcretion were evaluated. Results The high
polyphenolintake induced
ductus arteriosus
constrictionby 71.6% increase in systolic (P=0.001) and 57.8% in diastolic velocities (P=0.002), and 18.9% decrease in
pulsatility index(P=0.033), along with 1.7-fold increase in total
polyphenolexcretion, 2.3-fold decrease in inflammatory mediator nitric oxide and following redox status changes (mean±standard deviation): higher protein carbonyls (1.09±0.09 and 1.49±0.31), catalase (0.69±0.39 and 1.44±0.33) and
glutathione peroxidase(37.23±11.19 and 62.96±15.03) in addition to lower lipid damage (17.22±2.05 and 12.53±2.11) and nonprotein thiols (0.11±0.04 and 0.04±0.01) found before and after treatment, respectively. Ductal parameters correlated to NOx, catalase,
glutathione peroxidaseand protein carbonyl. Conclusion Our results highlight the need to reduce maternal PRF intake in late pregnancy to prevent fetal duct
constrictionthrough NO-mediated vasoconstrictive action of
polyphenols. © 2014 John Wiley & Sons, Ltd.
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